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Saeedeh Hashemian

Catalysis 2022
Saeedeh Hashemian, Speaker at Catalysis Conference
Islamic Azad University, Iran (Islamic Republic of)
Title : Synthesis of tetrazolo[1,5-a]pyrimidines derivatives by using nanocatalyst of ZIF supported on the red soil


Metal-organic frameworks (MOFs) have developed as promising crystalline materials because of their esthetically pleasing structures. The crystal structures of MOFs can be customized depending on the metal and ligand choice as also on the solvents and reaction conditions employed. ZIFs are porous crystalline materials consisting of tetrahedral clusters MN4 type (i.e., M = Co (II), Zn (II) connected with imidazolate linkers. ZIFs belong to MOFs subfamily with desirable chemical and physical properties like, porosity, crystallinity, structure diversity and exceptional thermal, chemical and water stabilities. Due to these features, ZIFs have shown potential applications for separation, gas storage, catalyst and adsorption. In view of above discussions, ZIFs appeared as efficient catalyst for synthesis of organic compounds. Tetrazolopyrimidines are reported to have been used in the treatment of obesity, diabetes, atherosclerosis, hyper-tension, coronary heart disease, hypercholesterolemia, hyperlipidemia, thyroid cancer, hypothyroidism, depression, glaucoma, cardiac arrhythmias, and congestive heart failure. Tetrazolo pyrimidines, nitrogen-bridgehead fused heterocycles containing a tetrazole ring, are a common structural motif in pharmacologically important molecules, with activities spanning a diverse range of targets. The development of simple synthetic methods for these derivatives is so important in organic synthesis. Different clays from different regions around the world have been previously characterized due to its importance for industrial applications. They consist of a multitude of different minerals. Red soil is inexpensive and has great mine and abundant in Hormozgan of Iran. The present study has developed an effective and ecofriendly route for the preparation of tetrazolo[1,5-a]pyrimidine derivatives by using nano catalyst of ZIF supported on the red soil. The structure and phase crystallites of ZIF supported on the red soil were investigated by FTIR and XRD. The surface morphology of sample was studied by FESEM method. The surface area of nano catalyst sample also investigated. The effect of different conditions for preparation of tetrazolo[1,5-a] pyrimidines in presence of nano catalyst was determined. Reusability of nanocatyst also investigated. The nano catalyst was useable after 5 cycles. The process was cost effective and hence ecofriendly.  

Audience take-away:

  • Easy and fast preparation of ZIF by Cu instead Zn.
  •  Prepare and characterization of ZIF supported on the red soil  
  • ZIF supported on the red soil was used as sufficient nano catalyst for one poet synthesis of tetrazolo[1,5-a] pyrimidines derivatives


Prof. Saeedeh Hashemian studied Chemistry at the Islamic Azad University of IRAN, Yazd Branch as Bachelor in applied chemistry in1991and graduated as MS in 1995 at same University.  She received her PhD degree in Science and Research Branch–Tehran (Islamic Azad University) in 2007. She received assistant Prof. in 2007. She obtained the position of an Associate Professor at 2011 and Full Prof at 2015. She has published more than 137 research articles in ISI Journals and 150 articles in national and international Conferences. She was 2% superior world science (2020 –Standford- J. PLOS) and (2021 –Standford- J. PLOS).