Title : Organocatalytic or Multicomponent approach to the synthesis of new pentasubstituted cyclopentenes
The asymmetric synthesis of cyclic compounds in special 5-membered carbocyclic ring systems is of grand importance, once this scaffold is widely found in numerous medicinal and biologically active compounds. 1 For this porpoise, metal transition catalyst is extensively used;2 however, the organocatalytic-multicomponent approach version has been an unexplored area. So, in this work, a sequential asymmetric organocatalytic tandem conjugated addition 3 followed by a multicomponent reaction was done. The reaction between propanal and (E)-2-(2-nitrovinyl)phenols was catalyzed by Jørgensen-Hayashi organocatalyst to produce the not isolated bifunctional chiral intermediate, which was reacted in presence of amines and isocyanides components by a Ugi MW procedure. Unexpected enatio- and diastereoselective fully substituted cyclopentenes in the yield range of 55-70% were obtained.