Ozlem Alptekin

Catalysis 2021
Ozlem  Alptekin, Speaker at 
Speaker for Catalysis Conference- Ozlem  Alptekin
Cukurova University, Turkey
Title : The role of the hydrolases in drug synthesis

Abstract:

Enzymes are molecules in most protein structures that catalyze important biochemical reactions in living organisms. But in the early 2000s, studies have shown that enzymes can also be used in drug synthesis. Chemical syntheses may damage the environment, require the use of chemicals that are expensive and potentially toxic to living organisms, often require additional steps for purification, and obtaining the desired enantiomers in these syntheses is difficult. For these reasons, researchers tended to use chemoenzymatic drug syntheses that are environmentally friendly, effective, efficient, and reusable. Enzymes are used in these syntheses. Hydrolase enzymes are one of the enzymes that are often used in drug synthesis. Hydrolases are enzymes that catalyze hydrolysis reactions. They are commonly used to obtain enantiomerically pure drug precursors in drug synthesis. Lipases were used in the synthesis of pregabalin which is an anticonvulsant drug, tryptase inhibitors, 15-deoxyspergualin which is an immunosuppressive agent, rasagiline used in the treatment of Parkinson disease, duloxetine which is an antidepressant drug, ibuprofen, ketoprofen, and naproxen which are nonsteroidal anti-inflammatory drugs and doxazosin which is an α1 – selective adrenergic antagonist. Esterases were used in the synthesis of doxazosin which is an α1 – selective adrenergic antagonist and glycosidases were used in the synthesis of rare ginsenosides. Epoxide hydrolases were used in the synthesis of propranolol which is a beta antagonist and linezolid which is an antibiotic. Peptidases were used in the synthesis of proteasome inhibitors, (+)-gamma-lactamases were used in the synthesis of abacavir which is an antiviral drug, and nitrilases were used in the synthesis of nicotinic acid. In addition, the importance and the advantages of chemoenzymatic syntheses, reactions catalyzed by these enzymes, results of synthesis, and the general information about used hydrolase enzymes were investigated in detail.

Biography:

Dr. Alptekin studied the Department of Chemistry at the Cukurova University, Turkey and graduated as MS in 2003. She received her PhD degree in 2009 at the same institution. After four years she obtained the position of Assist Professor at the Faculty of Pharmacy at Cukurova University. She has published more than 14 research articles in SCI(E) journals and 530 over cites.

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