Title : Effect of tunable redox behavior of bis chelate substituted1, 10 phenantroline Cu(II) complexes on its reaction with superoxide anion in DMSO. Toward a simple criterion to identify a SOD like mechanism
Abstract:
I n this work we report a series of Cu(II) complexes [Cu(N-N)2 (X)] +, (N-N = substituted 1,10-phenanthroline derivatives and X = Cl− or NO3 −), with tunable E1/2 for electrochemical reduction [CuII(N-N)2 (X)]+ + 1e− ? [CuI (N-N)2 ]+X−. The disproportion of O2 •− was explored in presence of the electro-generated species [CuI (N-N)2 ] + using cyclic voltammetry in a non-aqueous media, arising a new simple method to propose a SOD-like mechanism, which can be used as a quick guide test for a compound, before being proven in biological assays. It was found that complexes with high negative half wave potential values (E1/2) for Cu(II)/Cu (I) couple shown a current increment for oxygen reduction, related to the capability of the disproportion of this reactive oxygen species.
